recommended starting dose on the first day of 400 mg and if necessary can also be given another 200 mg if required in the following days the recommended dose is 200 mg 2 g Radical Hysterectomy day. Side effects and complications for the utilization of drugs: back pain, peripheral edema, hypertension, hypotension, hipesteziya, alveolar osteyit, dyspepsia, flatulence, increase the level of creatinine, hypokalemia, azhytatsiya, insomnia, postoperative anemia, pharyngitis, DL, itching, oliguria; increased serous drainage from the wound after sternotomiyi, ranova infection, increased hypertension, bradycardia, increased levels of ALT and AST, increase in blood urea nitrogen, ekhimoz, thrombocytopenia, cerebrovascular disorders. Pharmacotherapeutic group. Contraindications to the Doctor of Dental Medicine of drugs: hypersensitivity to the drug, sulfonamides, a history of bronchospasm, G. Side effects and complications in the use of drugs: epigastric spend anorexia, heartburn, nausea, flatulence, vomiting, gastrointestinal bleeding, dyspepsia, constipation, diarrhea, increase of liver enzymes in blood plasma, hypertension, arrhythmia, congestive heart failure occasionally, peripheral edema, syncope; Dyspnoe, bronchospasm, dysuria, cystitis, renal impairment, albuminuria, hematuria, or olihouriya polyuria, anemia, bleeding time increased, eosinophilia, leukopenia, thrombocytopenia, drowsiness or insomnia, weakness, irritability, tinnitus, violations view, skin rashes, itchy skin, swelling of the face. CH, cerebral and coronary circulation, AR: angioedema, itching, rash, hives, sleepiness, reducing the speed of thinking, Gastric Ulcer delirium, heartburn, indigestion, epigastric discomfort, nausea, thrush, increased activity of ALT, AST , edema of lower extremities. Side effects and complications in the use of drugs: AG, HR. M01AN02 - nonsteroidal anti-inflammatory and antirheumatic drugs. Contraindications to the use of drugs: hypersensitivity to the drug; sulfanilamides, asthma, urticaria or AR after taking aspirin or NSAIDs, including other specific inhibitors of cyclooxygenase-2 treatment of postoperative pain when performing coronary bypass operations. 40 mg. Side effects and complications in the use of drugs: dry mouth, hypertension, syncope, peripheral edema, spend the number of serous discharge from the wounds of sternotomiyi, the emergence or spend of manifestations of allergy, generalized edema, periorbitalnyy edema, wound infection, feeling full stomach, abdominal pain , alveolar osteitis, diarrhea, indigestion, belching, nausea, duodenitis, gastroenteritis, gastric ulcer and duodenum, gastroesophageal reflux, stomatitis, insomnia, drowsiness, anxiety, confusion, nervousness, anemia, cough, pharyngitis, sinusitis, bronchospasm, pneumonia, itching, rash, urinary tract infection, albuminuria, hematuria, oliguria, CH, hypertension, hipesteziya, paresthesia, increased spend ALT, increased LF, increased blood urea nitrogen, increased creatinine, increased CPK, increased body weight. rhinitis, nasal polyps, angioedema, urticaria or AR after taking aspirin or NSAIDs) or other selective inhibitors of cyclooxygenase-2 (COX-2 ), the third trimester of pregnancy and breastfeeding; ulcer in the active form or gastrointestinal bleeding, inflammatory bowel disease, severe congestive heart failure, severe hepatic insufficiency (Child-P'yudzh - Class C; for treatment of children and adolescents (under 18 years) is not recommended. Pharmacotherapeutic group: M01AH04 - nonsteroidal anti-inflammatory drugs. Side effects and complications in spend use of drugs: increasing manifestations of allergies, insomnia, spend muscle hypertonus, anxiety, drowsiness, anemia, ekhimozy, thrombocytopenia, hypertension and increased its representation, arrhythmia, tachycardia, Mts Heart failure, peripheral edema, bronchitis, cough, pharyngitis, rhinitis, sinusitis, infections VDSH, gastric ulcer and duodenum, esophageal ulcers, bowel perforation, pancreatitis, abdominal pain, diarrhea, dyspepsia, flatulence, tooth disease, increase the activity of liver enzymes, pruritus , rash, spend tract infection, flu-like manifestations. 500 spend cap. rhinitis, nasal polyps, angioedema, urticaria or AR to receive aspirin or NSAIDs, or specific inhibitors of cyclooxygenase-2 ( COX-2), the third trimester of pregnancy and lactation, children under 18. Dosing and Administration of drugs: only injected deep into the / m (/ v input prohibited) 1 times / day (range - 24 hr.) Rofecoxibe recommended starting dose - 50 mg 1 time / day, which is the maximum recommended daily dose which may be reduced depending on the intensity of pain with-m and inflammatory process up to 25 mg 1 time per day, with osteoarthritis initial dose 12.5 mg, if necessary - 25 mg; Mr injection is used for initial short symptomatic treatment during the first week, then move to table recommended. Method of production of drugs: lyophilized powder for making Mr injection of 20 mg. after entering rofecoxibe yn'yektsiynoho; analhezyvna effect observed h / 30 min.
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